ASE Annual Conference 2019

Viral infections are estimated to cause over 10% of all cancers, resulting in over 1.3 million deaths a year worldwide. Human papillomavirus (HPV) infections cause almost half of these cancers, including cancers of the genital and oral cavities. The causal link between HPV and cancer development is established and many of the fundamental mechanisms driving HPV-induced disease are well characterised. In this session, I will explain how the virus manipulates the host to drive cancer development. I will then give an overview of unanswered and important questions regarding HPV-driven disease and how my research group is tackling these questions using cell-based models of HPV infected skin.